Do you run into any latency issues with the RME firefaces when sending audio out to your hardware and then recording back into the computer?

Ott responded on 02/08/2013

I run them with small buffers so my latency is sub-5ms but the RME TotalMix software allows me to route the signals in such a way as I can monitor mic inputs with zero latency.

When using external insert fx I use Cubase's excellent external FX routing which automatically adjusts for latency.

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